Alternatives to animal testing in basic and preclinical research of atopic dermatitis
نویسندگان
چکیده
منابع مشابه
Alternatives to animal experimentation in basic research.
In contrast to animal testing required by law to guarantee minimum safety standards for the licensing of drugs and chemicals, there are no regulations in basic research forcing scientists to perform animal tests. By (usually) free choice, questions are posed and hypotheses are examined which, in many cases, can only be answered by means of animal tests. Just as easily, different questions could...
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There is a medical need to develop new treatments for patients suffering from atopic dermatitis (AD). To improve the discovery and testing of novel treatments, relevant animal models for AD are needed. Generally, these animal models mimic different aspects of the pathophysiology of human AD, such as skin barrier defects and Th2 immune bias with additional Th1 and Th22, and in some populations T...
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Bladder cancer is one of the most common cancers in the world. In 2006, there were about 61,240 diagnosed cases of bladder cancer and approximately 13,060 deaths attributable to this disease, being the prevalence estimated worldwide more than 1,000,000 patients (Jemal et al., 2006; Lerner, 2005). Taking into account that its incidence seems to be increasing, bladder cancer is clearly a signific...
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Current trends and issues in the development of alternatives to the use of animals in biomedical experimentation are discussed in this position paper. Eight topics are considered and include refinement of acute toxicity assays; eye corrosion/irritation alternatives; skin corrosion/irritation alternatives; contact sensitization alternatives; developmental/reproductive testing alternatives; genet...
متن کاملAlternatives in animal testing.
1Division of Hematology/Oncology, Department of Medicine, Health Science Center, University of Florida, P.O. Box 100277, Gainesville, FL 32610, USA 2Division of Cardiology, Department of Medicine, Health Science Center, University of Florida, P.O. Box 100277, Gainesville, FL 32610, USA 3Department of Pathology, Health Science Center, University of Florida, P.O. Box 100277, Gainesville, FL 32610...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2018
ISSN: 0906-6705
DOI: 10.1111/exd.13498